Live Telecast, "STEM CELL THERAPY & NEUROLOGICAL DISORDERS" on 21st April 2018 at 3.30 PM on Z-24TAAS_HITGUJ By Dr. Anant Bagul   :*: Upcomming Events: “2ND INTERNATIONAL REGENERATIVE MEDICINE CONCLAVE ON 13TH MAY 2018”  

Spinal Injuries

A spinal injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. The damage begins at the moment of injury when displaced bone fragments, disc material or ligaments bruise or tear into spinal tissue. Spinal injuries cause myelopathy or damage to nerve roots or myelinated fiber tracts that carry signals to and from the brain. Depending on its classification and severity, this type of traumatic injury could also damage the grey matter in the central part of the causing segmental losses of interneurons and motorneurons. Most injuries to the spinal don't completely sever it. Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy the axons, extensions of nerve cells that carry signals up and down the spinal between the brain and the rest of the body. An injury to the spinal can damage a few or almost all of these axons. Some injuries will allow almost complete recovery while others will result in complete paralysis.

Spinal cord injury research Spinal cord injury research

Therapeutic use of Stem cells

Stem cell derived from human bone marrow improves mobility with spinal injuries providing the first physical evidence that the therapeutic use of these cells can help restore motor skills lost from acute spinal cord tissue damage.
Patients are clinical by injecting the stem cells directly into damaged area or in the cerebrospinal fluid which flows within the spinal canal. This procedure is called intrathecal injection or lumbar puncture.
After the clinical trial, improvements were reported by patients with both incomplete and complete injuries. Regaining sensation was reported by 60 patients. More than two-thirds reported increased muscle strength and improved endurance. Post clinical trial about 26 – 41 % patients experienced better bladder and bowel control and improved erections. Over 50% patients reported decreased spasticity and limb pain.
An injured spinal loses its ability to regenerate myelin-forming cells leading to paralysis. Fehlings showed that where stem cells restored myelin in the injured spine, rats showed some recovery and walked with more coordination. Stem cell research has the potential to save the lives of those afflicted by many medical conditions including spinal injury.
Every year India gets over 20,000 cases of spinal injury patients. A new Mesenchymal stem cell (MSC) could be the answer for these patients. The research conducted by a team of doctors at Bangalore-based Stempeutics Research, has shown promising results. In the pilot study, MSCs were injected directly into the spinal of the patient for maximum efficacy. It was injected either intra-arterially or through intra-spinal (site of injury) route. This new technique of injecting stem cells close to the site of injury showed good results.

Stem Cells & Spinal Injury

Stem cell can be defined as a part of a group of new techniques or technologies that rely on replacing diseased or dysfunctional cells with healthy functioning ones. These new techniques are being applied experimentally to a wide range of human disorders including many types of cancer, neurological diseases such as Parkinson's disease and ALS (Lou Gehrig's disease), spinal injuries and diabetes.

Few facts about the stem cells
  • Stem cell is non invasive procedure which does not require any stitch, dissection or tissues manipulation. In adults it can be undertaken under local aesthesia. Children may need tranquiliser or short aesthesia for five minutes only.
  • Bone marrow Transplantation is autologous, so there is no fear of rejection or mismatch or need for immunosuppressant required in other transplantation surgeries.
  • AUTOLOGOUS stem cells are safe .
  • Good results are documented in otherwise dead-end patients. Other clinical trial modalities are only supportive and empirical.