Live Telecast, "STEM CELL THERAPY & NEUROLOGICAL DISORDERS" on 21st April 2018 at 3.30 PM on Z-24TAAS_HITGUJ By Dr. Anant Bagul   :*: Upcomming Events: “2ND INTERNATIONAL REGENERATIVE MEDICINE CONCLAVE ON 13TH MAY 2018”  

Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown cause. The hallmark feature of this condition is persistent symmetric polyarthritis (synovitis) that affects the hands and feet, although any joint lined by a synovial membrane may be involved. Extra-articular involvement of organs such as the skin, heart, lungs, and eyes can be significant.

The cause of RA is unknown. It is an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue.

RA can occur at any age, but is more common in middle age. Women get RA more often than men.

Infection, genes, and hormone changes may be linked to the disease.

An external trigger (eg, infection, trauma) that triggers an autoimmune reaction, leading to synovial hypertrophy and chronic joint inflammation along with the potential for extra-articular manifestations, is theorized to occur in genetically susceptible individuals. Synovial cell hyperplasia and endothelial cell activation are early events in the pathologic process that progresses to uncontrolled inflammation and consequent cartilage and bone destruction. Genetic factors and immune system abnormalities contribute to disease propagation.

There is no cure for rheumatoid arthritis. Medications can reduce inflammation in your joints in order to relieve pain and prevent or slow joint damage. Occupational and physical can teach you how to protect your joints. If your joints are severely damaged by rheumatoid arthritis, surgery may be necessary.

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Stem cell will work in RA in three way one is the restoration of damaged joint tissue by stimulating the patient's own regenerative resources under the influence of growth factors produced by cells, replenishment of stem reserves for regeneration of synovial, cartilage and bone tissue by mesenchymal cells, eliminating of disease autoimmune component and blocking of disease further progression due to immunosuppressive and tolerogen effects of mesenchymal and hematopoietic stem cells.

There are a number of advantages to using human that do not require immune suppression and which can help balance immune function by changing the genetics of the immune reactive cells.

Rheumatoid Arthritis research Rheumatoid Arthritis research