Live Telecast, "STEM CELL THERAPY & NEUROLOGICAL DISORDERS" on 21st April 2018 at 3.30 PM on Z-24TAAS_HITGUJ By Dr. Anant Bagul   :*: Upcomming Events: “2ND INTERNATIONAL REGENERATIVE MEDICINE CONCLAVE ON 13TH MAY 2018”  

Muscular Dystrophy

Muscular Dystrophy is an autosomal recessive genetic disorder that weakens the muscles which are responsible for the movement of the body. A person with muscular dystrophy is not able to produce dystrophin protein. Dystrophin is essential for integrity of muscle fibre. Absences of dystrophin lead to slow destruction of muscle over a period of time making it difficult for a person to perform even basic movements like walking and sitting up.

When clinical Muscular Dystrophy lack of protein is a major concern. However use of driven mesenchymal cells will provide healthy genes and stem cell transplantation may reset up the blood-making function, decrease the serum CK level, restore the dystrophin in muscles and improve the locomotive function of the DMD patients.

As per previous study of Literature, after allogenic stem cell transplantation, DNA analysis showed that the donor's gene DNA accounted for 1%-13%. At 126 days, obviously increased dystrophin positive muscular fibres of the boy were found. The donor's fibres rose to 2.5%-25%. The serum CK of the boy declined from 5735 U/L to 274 U/L. At 100 days, physical examination revealed improvement in arms and leg.

Muscular Dystropy research Muscular Dystropy research
Muscular Dystropy research
Few facts about the stem cells
  • Stem cell is non invasive procedure which does not require any stitch, dissection or tissues manipulation. In adults it can be undertaken under local aesthesia. Children may need tranquiliser or short aesthesia for five minutes only.
  • Bone marrow Transplantation is autologous, so there is no fear of rejection or mismatch or need for immunosuppressant required in other transplantation surgeries.
  • AUTOLOGOUS stem cells are safe .
  • Good results are documented in otherwise dead-end patients. Other clinical trial modalities are only supportive and empirical.