Live Telecast, "STEM CELL THERAPY & NEUROLOGICAL DISORDERS" on 21st April 2018 at 3.30 PM on Z-24TAAS_HITGUJ By Dr. Anant Bagul   :*: Upcomming Events: “2ND INTERNATIONAL REGENERATIVE MEDICINE CONCLAVE ON 13TH MAY 2018”  

Liver Diseases

Liver disease is a broad term describing any single ailment affecting the liver. These diseases cause liver inflammation or tissue damage disrupting the functioning of liver. Infection, injury, exposure to drugs or toxic components or genetic defect can all lead to liver diseases.

The worldwide shortage of donor livers to transplant end stage liver disease patients has prompted the search for alternative cell therapies for intractable liver diseases, such as acute liver failure, cirrhosis and hepatocellular carcinoma (HCC). Under normal circumstances the liver undergoes a low rate of hepatocyte wear and tear renewal but can mount a brisk regenerative response to the acute loss of two-thirds or more of the parenchymal mass.

A body of evidence favours placement of a stem cell niche in the periportal regions, although the identity of such stem cells in rodents and man is far from clear. In animal models of liver disease, adopting strategies to provide a selective advantage for transplanted hepatocytes has proved highly effective in repopulating recipient livers, but the poor success of today's hepatocyte transplants can be attributed to the lack of a clinically applicable procedure to force a similar repopulation of the human liver.

The activation of bipotential hepatic progenitor cells (HPCs) is clearly vital for survival in many cases of acute liver failure and the signals that promote such reactions are being elucidated. Bone marrow cells (BMCs) make, at best, a trivial contribution to hepatocyte replacement after damage, but other BMCs contribute to the hepatic collagen-producing cell population, resulting in fibrotic disease; paradoxically, BMC transplantation may help alleviate established fibrotic disease.

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e number of sessions may vary from patient to patient. Few facts about the stem cells
  • Stem cell is non invasive procedure which does not require any stitch, dissection or tissues manipulation. In adults it can be undertaken under local aesthesia. Children may need tranquiliser or short aesthesia for five minutes only.
  • Bone marrow Transplantation is autologous, so there is no fear of rejection or mismatch or need for immunosuppressant required in other transplantation surgeries.
  • AUTOLOGOUS stem cells are safe .
  • Good results are documented in otherwise dead-end patients. Other clinicle trial modalities are only supportive and empirical.
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