Live Telecast, "STEM CELL THERAPY & NEUROLOGICAL DISORDERS" on 21st April 2018 at 3.30 PM on Z-24TAAS_HITGUJ By Dr. Anant Bagul   :*: Upcomming Events: “2ND INTERNATIONAL REGENERATIVE MEDICINE CONCLAVE ON 13TH MAY 2018”  

Huntington's Disease

Huntington's disease (HD) is a fatal hereditary disease that destroys neurons in areas of the brain involved in movement, intellect, and emotions. The course of Huntington's is characterized by jerking uncontrollable movement of the limbs, trunk, and face (chorea); progressive loss of mental abilities; and the development of psychiatric problems.

Nerve cells become damaged, causing various parts of the brain to deteriorate. The disease affects movement, behavior and cognition - the affected individuals' abilities to walk, think, reason and talk are gradually eroded to such a point that they eventually become entirely reliant on other people for their care. Huntington's disease has a major emotional, mental, social and economic impact on the lives of patients, as well as their families.

The disease is caused by an autosomal dominant mutation on either of an individual's two copies of a gene called Huntingtin.

In this there is a Degeneration of the caudate and the putamen (striatum) . There is also neuronal loss and astrogliosis, as well as loss of medium spiny neurons, a GABAergic result. Intranuclear inclusions that stain for ubiquitin and huntingtin can be seen, as well as huntingtin in cortical neurites. Genetically, huntingtin is found on chromosome 4, as are CAG repeats.

There is no cure. Medicines can help manage some of the symptoms, but cannot slow down or stop the disease.

Few facts about the stem cells
  • Stem cell is non invasive procedure which does not require any stitch, dissection or tissues manipulation. In adults it can be undertaken under local aesthesia. Children may need tranquiliser or short aesthesia for five minutes only.
  • Bone marrow Transplantation is autologous, so there is no fear of rejection or mismatch or need for immunosuppressant required in other transplantation surgeries.
  • AUTOLOGOUS stem cells are safe .
  • Good results are documented in otherwise dead-end patients. Other clinical trial modalities are only supportive and empirical.