Live Telecast, "STEM CELL THERAPY & NEUROLOGICAL DISORDERS" on 21st April 2018 at 3.30 PM on Z-24TAAS_HITGUJ By Dr. Anant Bagul   :*: Upcomming Events: “2ND INTERNATIONAL REGENERATIVE MEDICINE CONCLAVE ON 13TH MAY 2018”  

Diabetes

We would be happy to welcome you in our Chaitanya stem cell institute, pune. Pl Undertake following investigations urgently and bring reports when you will be visiting our Chaitanya Stem Cell Research Center at Pune.
  • Haemogram with ESR
  • B.S.L. F / PP2
  • Glycosylated Hemoglobin
  • C-reactive protein
  • L.F.T
  • R.F.T.
  • Anti G.A.D. Antibodies
Diabetes mellitus will frequently reach the stage of life threatening and severely disabling complications the progress of which cannot be controlled by insulin alone. It has been known for decades that stem cell transplantation is the sole available for such advanced stages of diabetes.
There are published data about several thousands of diabetics that have been so handled in clinical practice with ever growing success during the last 70 years, but the total number of diabetics among ~ 5 million patients that underwent stem cell is obviously much larger. Diabetes Mellitus, types 1 and mixed 1/2, particularly with complications, such as
  • Diabetic Retinopathy
  • Diabetic Nephropathy
  • Diabetic Polyneuropathy
  • Diabetic Lower Extremity Arterial Disease
This applies also to
  • Brittle Diabetes Mellitus in children
  • Diabetes Mellitus in pregnancy, or diabetes mellitus as a cause of female infertility and habitual pregnancy loss
  • Diabetic retinopathy
  • Diabetic nephropathy
  • Diabetic polyneuropathy
  • Diabetic lower extremity arterial disease
By its method of cell transplantation, described in this web site.the success rate of clinical trial our method of stem cell transplantation has been for:
  • Diabetic retinopathy in pre-proliferative stage 55%
  • Diabetic nephropathy in pre-uremic stage 50%
  • Diabetic polyneuropathy 78%
  • Diabetic lower extremity arterial disease in pre-gangrene stage 55%

The sooner the patient receives stem cell transplantation after the diagnosis of diabetic complication was established, the better will be the success rate of such stem cell. Up to 70% of children with therapeutically uncontrollable 'brittle' diabetes had already developed typical diabetic complications by the time of their referral for stem cell transplantation, and such patients benefit from such in 65% of cases. Unknown number of children with recent onset of diabetes mellitus have been treated successfully with stem cell transplantation: there have been some cures, and in other patients at least a delay in the onset of diabetic condition. If one could postpone the onset of child's diabetes by one or more years, it would be of tremendous value because of well known deleterious effect of diabetic condition on growth and development of such children.

When a woman diabetic has been under clinicle trial for infertility for over a year without a success, stem cell transplantation should be strongly considered.
If a woman with diabetes mellitus have had 2 – 3 miscarriages, stem cell transplantation is indicated.

When a pregnant diabetic delivered a baby with a diabetic fetal distress syndrome, stem cell transplantation should be carried out before her next pregnancy, or even during her next pregnancy (between 12th and 16th week).
The preparation of stem cell transplants by our method, that includes a unique system of primary tissue culture, which lowers the immunogenicity of the stem cell transplants to such a degree that no immunosuppression is necessary, and that is of great importance particularly for the clinical trial of diabetes mellitus.
Besides well known side-effects the specific problem of immunosuppression in diabetics is that it causes an increased metabolic demand on beta cells of pancreatic islets so that their capacity to produce insulin may be exhausted.

This deleterious effect is much greater for islet cell transplants than for organ transplants of pancreas.
Already in the 30s, Alexis Carrel, Nobel Prize winner in physiology, stated that insulin cannot cure diabetes mellitus, only cell transplantation can . This statement is still valid today - even after the widely promoted DCCT trial in the U.S.
Insulin prevents death of a new diabetic but cannot stop the development of dreaded diabetic complications, severely disabling, and frequently deadly after years of suffering.
The cause of all diabetic complications is still unknown but it is probably due to the lack of other - still unknown - hormones produced by various cells of Langerhans islets of pancreas, or by different cells of various organs of the regulatory system of carbohydrate and lipid metabolism.

As the clinical experience of the past four decades have shown only stem cell transplantation can stop the relentless progress of the complications of diabetes mellitus once they start.
This implies that the transplanted cells of all organs and tissues involved in carbohydrate metabolism produce - directly or indirectly - the missing (endocrine or paracrine) hormones.
According to the National survey, India is a capital if Diabetes .

Diabetic nephropathy, the leading cause of end-stage kidney disease in U.S. requiring artificial kidney clinical trial (hemodialysis) & kidney organ transplantation, develops in 35% of all diabetics, after 15 years 25% of diabetics will have protein in urine, and of those 50% of IDDM patients and 11% of NIDDM patients will be on kidney dialysis within 10 years; Diabetic polyneuropathy will develop after 15 years in 30 - 70% of diabetics, equally in IDDM and NIDDM patients; Diabetic lower extremity arterial disease has been the cause of one half of all leg amputations .

Diabetes mellitus is 7th leading cause of death in india.: 400,000 deaths reported each year. Diabetics have much higher incidence of heart disease, at an earlier age, and with fatal prognosis, than non-diabetics. Diabetics have 2.5. times higher risk of stroke than non-diabetics.
Many digestive diseases, infections, dental problems, depressions, are substantially more common in diabetics than non-diabetics. The above statistics have gotten worse since 1995. Organ transplantation of pancreas has been carried out for several years, but even today it amounts to only ~ 1,300 patients a year worldwide, because of high complications rate. For that reason it has been usually carried out only in conjunction with kidney transplantation.
However, as time goes by, the consequences of both types of diabetes become increasingly serious and can lead to death. These include heart disease, eye problems, kidney failure, nerve damage and erectile dysfunction, to name a few. Major contributors to the degenerative effects of diabetes are hyperglycemia (high blood sugar) and hypoglycemic events (acute low blood sugar). Recent studies suggest that even some oral diabetes medications contribute to heart failure. Thus, it is critical that men and women who are diagnosed with diabetes seek clinical trial to reduce hyperglycemia and hypoglycemic events that will, in time, trigger these dangerous, degenerative conditions.

Diabetes research Diabetes research


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